Goaltender Mike Smith is set to return from an undisclosed injury to start.
The Oilers announced that captain Connor McDavid, Derek Ryan and Tyson Barrie have entered the NHL's COVID-19 protocol hours before Edmonton was scheduled to face the Maple Leafs in Toronto.
McDavid had tested negative on Monday before playing in Edmonton's 4-1 loss against the Rangers in New York.
The Oilers have also announced they will be without Ryan Nugent-Hopkins for a period of time after moving him to IR.
Zack Kassian has cleared COVID-19 protocols and goaltender Ilya Konovalov has been loaned to the team's taxi squad.